KMID : 1129720050220010023
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Korean Journal of Acupuncture 2005 Volume.22 No. 1 p.23 ~ p.32
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Effect of Ephedrae Herbal Acupuncture Solution(EHS) on the Release of Thymus and Activation-Regulated Chemokine (TARC) in Human Bronchial Epithelial Cell
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Chou Yu-Shih
Seo Jung-Chul Lim Seong-Chul Jung Tae-Young Han Sang-Won
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Abstract
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Chemokines are important for the recruitment of leukocytes, which is essential in host defense to the sites of infection. The thymus and activation-regulated chemokine (TARC) is a CC chemokine which potentially plays a role via a paracrine mechanism in the development of allergic respiratory diseases.
Objectives : The objective of this study is to investigate the effect of Ephedrae Herba Herbal Acupuncture Solution(EHS) on the secretion of TARC of human bronchial epithelial cell.
Methods : Enzyme-linked immunosorbent assay (ELISA) was performed to detect the secretion of TARC. The cytotoxicity was measured by MTT assay.
Results : EHS significantly inhibited the secretion of TARC with a dose-dependant manner. The effective dosage did not have the cytotoxicity on human bronchial epithelial cell.
Conclusion : Results of our study imply that EHS would play an important role in modulation of TARC in human bronchial epithelial cells by MTT assay
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KEYWORD
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Ephedrae Herba Herbal Acupuncture Solution(EHS), thymus and activation-regulated chemokine (TARC), Human bronchial epithelial cells, A549
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